Therapeutic targeting of circ‐ CUX 1 / EWSR 1/ MAZ axis inhibits glycolysis and neuroblastoma progression

Cux 1

Early studies suggested that the expression of CUX1 in mammalians is restricted to proliferating and undifferentiated cells (20, 27, 28). However, more recent publications demonstrated that CUX1 expression can also be found in terminally differentiated cells of several tissues (5, 10). Proteolytic processing of the full length protein (p200) by Cathepsin L and other not yet identified proteases...

Targeting posttranslational modifications of RIOK 1 inhibits the 1 progression of colorectal and gastric cancers

PARP-1 inhibits glycolysis in ischemic kidneys.

After ischemic renal injury (IRI), selective damage occurs in the S(3) segments of the proximal tubules as a result of inhibition of glycolysis, but the mechanism of this inhibition is unknown. We previously reported that inhibition of poly(ADP-ribose) polymerase-1 (PARP-1) activity protects against ischemia-induced necrosis in proximal tubules by preserving ATP levels. Here, we tested whether ...

Chapter 1 CIRC

CIRC is an automated circular coinductive prover that is implemented as an extension of Maude. CIRC implements the circularity principle, which generalizes circular coinductive deduction [4] and can be expressed in plain English as follows. Assume that each equation of interest (to be proved) e admits a frozen form fr(e) and a set of derived equations, its derivatives, Der(e). The circularity p...

Chapter 1 CIRC Tutorial

CIRC is an automated circular coinductive prover that is implemented as an extension of Maude. CIRC implements the circularity principle, which generalizes circular coinductive deduction [4] and can be expressed in plain English as follows. Assume that each equation of interest (to be proved) e admits a frozen form fr(e) and a set of derived equations, its derivatives, Der(e). The circularity p...